Tachykinins Play a Major Role in Micro and Macrovascular Complications in Type 2 Diabetes Patients

Title:Tachykinins Play a Major Role in Micro and Macrovascular Complications in Type 2 Diabetes Patients

Volume: 20 Issue: 3

Author(s): Faiqah Ramzan, Laila Kiran, Shumaila Noreen Malik and Muhammad Inamullah Malik*

Affiliation:

• Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan, Pakistan

Keywords: Diabetes, neuropeptides, neurosensory, tachykinins, vascular complications, neuropeptides.

Abstract: Diabetes Mellitus is a metabolic disorder, which is characterized by an increase in blood glucose levels. The defects in the secretion or action of insulin are the major cause of diabetes. Increase in the blood glucose level exerts a negative effect on the normal functions of the body organs and this leads to the dysfunctions of cells and tissue and causes vascular complications in diabetic patients. Several studies indicate that neuropeptides are released from the neurosensory cells which are mainly known as tachykinins which provoke major vascular complications in diabetic patients. Tachykinins are known as pro-inflammatory peptides which increase vascular complications and vascular permeability. The duration and severity of diabetes disease increase the risk of vascular complication in patients. The aim of this review is to elaborate the role of tachykinins in microvascular and macrovascular complications in diabetic patients. The study concluded that tachykinins increase micro and macrovascular complications in diabetic patients.

Cite this article as:

Ramzan Faiqah, Kiran Laila, Malik Noreen Shumaila and Malik Inamullah Muhammad*, Tachykinins Play a Major Role in Micro and Macrovascular Complications in Type 2 Diabetes Patients, Current Diabetes Reviews 2024; 20 (3) : e050523216590 . https://dx.doi.org/10.2174/1573399819666230505123844