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Current Cardiology Reviews


ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Review Article

Myocardial Infarction as a Consequence of Mitochondrial Dysfunction

Author(s): Pranay Wal*, Namra Aziz, Yash Kumar Singh, Ankita Wal, Sourabh Kosey and Awani Kumar Rai

Volume 19, Issue 6, 2023

Published on: 12 June, 2023

Article ID: e080523216642 Pages: 8

DOI: 10.2174/1573403X19666230508114311

Price: $65


Acute myocardial infarction is an event of myocardial necrosis caused by unstable ischemic syndrome. Myocardial infarction (MI) occurs when blood stops flowing to the cardiac tissue or myocardium and the heart muscle gets damaged due to poor perfusion and reduced oxygen supply. Mitochondria can serve as the arbiter of cell fate in response to stress. Oxidative metabolism is the function of mitochondria within the cell. Cardiac cells being highly oxidative tissue generates about 90% of their energy through oxidative metabolism. In this review, we focused on the role of mitochondria in energy generation in myocytes as well as its consequences on heart cells causing cell damage. The role of mitochondrial dysfunction due to oxidative stress, production of reactive oxygen species, and anaerobic production of lactate as a failure of oxidative metabolism are also discussed.

Keywords: Myocardial Infarction (MI), mitochondrial dysfunction, calcium overload, reactive oxygen species, cell damage, oxidative stress apoptosis.

Graphical Abstract
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