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Current Bioinformatics


ISSN (Print): 1574-8936
ISSN (Online): 2212-392X

Research Article

A Pan-cancer Analysis Reveals the Tissue Specificity and Prognostic Impact of Angiogenesis-associated Genes in Human Cancers

Author(s): Zhenshen Bao, Minzhen Liao, Wanqi Dong, Yanhao Huo, Xianbin Li*, Peng Xu* and Wenbin Liu*

Volume 18, Issue 8, 2023

Published on: 07 July, 2023

Page: [670 - 679] Pages: 10

DOI: 10.2174/1574893618666230518163353

Price: $65


Introduction: Angiogenesis is one of the hallmarks of cancer and can impact the processes of cancer initiation, progression, and response to therapy.

Background: Anti-angiogenic therapy is thus an encouraging therapeutic option to treat cancers, but the detailed angiogenic mechanisms and the association between angiogenesis and clinical outcome remain unknown in different cancers.

Methods: Here, we systematically assess the impacts of 82 angiogenesis-associated genes (AAGs) in tumor tissue specificity and prognosis across 16 cancer types.

Results: Results demonstrate that the expression patterns of the 82 AAGs can reflect the tumor tissue specificity, and high expressions of up-regulated AAGs are significantly associated with poor prognosis of cancer. We further define a prognostic score for predicting overall survival (OS) based on the expressions of up-regulated AAGs and confirm its reliable predictive ability. Results indicate that a low prognostic score demonstrates a superior OS and vice versa.

Conclusion: The results of this study will contribute to the understanding of different tumor angiogenesis mechanisms in various tissues and cancer-personalized anti-angiogenic treatment. The code of our analysis can be accessed at

Keywords: Angiogenesis, AAGs, systematically, poor prognosis, overall survival, personalized.

Graphical Abstract
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