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Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

The Influence of KIR Gene Polymorphisms and KIR-ligand Binding on Outcomes in Hematologic Malignancies following Haploidentical Stem Cell Transplantation: A Comprehensive Review

Author(s): Tahereh Bakhtiari, Mohammad Ahmadvand, Arash Salmaninejad, Afshin Ghaderi, Marjan Yaghmaie, Alireza Sadeghi, Seied Asadollah Mousavi, Tahereh Rostami* and Mazdak Ganjalikhani-Hakemi*

Volume 23, Issue 11, 2023

Published on: 15 June, 2023

Page: [868 - 878] Pages: 11

DOI: 10.2174/1568009623666230523155808

Price: $65

Abstract

Natural killer (NK) cell behavior and function are controlled by a balance between negative or positive signals generated by an extensive array of activating and inhibiting receptors, including killer cell immunoglobulin-like receptor (KIR) proteins, main components of the innate immune system that contribute to initial responses against viral infected-transformed cells through generation of the release of cytokines and cytotoxicity. What is certain is that KIRs are genetically polymorphic and the extent of KIRs diversity within the individuals may have the potential outcomes for hematopoietic stem cell transplantation (HSCT). In this regard, recent studies suggest that KIR is as imperative as its ligand (HLA) in stem cell transplantation for malignant diseases. However, unlike HLA epitope mismatches, which are well-known causes of NK alloreactivity, a complete understanding of KIR genes' role in HSCT remains unclear. Because of genetic variability in KIR gene content, allelic polymorphism, and cell-surface expression among individuals, an appropriate selection of donors based on HLA and KIR profiles is crucial to improve outcomes of stem cell transplantation. In addition, the impact of the KIR/HLA interaction on HSCT outcomes needs to be investigated more comprehensively. The present work aimed to review the NK cell regeneration, KIR gene polymorphisms, and KIRligand binding on outcomes in hematologic malignancies following haploidentical stem cell transplantation. Comprehensive data gathered from the literature can provide new insight into the significance of KIR matching status in transplantations.

Keywords: NK cell alloreactivity, KIR gene polymorphisms, KIR mismatching, haploidentical stem cell transplantation, killer cell immunoglobulin-like receptor, hematopoietic, stem cell transplantation.

Graphical Abstract
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