A large number of antibiotics are easily accessible for the treatment of various microbial infections. However, antibiotic resistance has become a major concern to public health across the globe. Carbazole derivatives are present in carbazomycins, an unprecedented class of antibiotics showing potential antibacterial activities. As reported in the literature, carbazole derivatives also possess significant antimicrobial activities against bacterial resistance, such as Methicillin Resistant Staphylococcus aureus (MRSA). The antimicrobial profile of carbazole derivatives has been achieved through various bacterial pathways. Carbazole hybrids based on the multi-target direct ligand (MTDL) approach were also extensively studied as they exhibited significant antibacterial activities. This article reviews antimicrobial potential, docking analysis, and structure-activity relationship (SAR) studies of carbazole and its derivatives against tested bacterial strains from 2014 to 2022. This review can also be helpful for investigators in the design and development of new molecules based on carbazole structure against various resistant bacterial infections.