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Endocrine, Metabolic & Immune Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Review Article

Naturally Occurring Herbs and their Bioactive Metabolites: Potential Targets and Signaling Pathways of Antiviral Agents

Author(s): Sonia Singh*, Shiwangi Sharma and Himanshu Sharma

Volume 23, Issue 12, 2023

Published on: 24 July, 2023

Page: [1505 - 1537] Pages: 33

DOI: 10.2174/1871530323666230622122901

Price: $65

Abstract

Viruses significantly impact global health because they are the leading cause of death everywhere they are found. Despite the rapid development of human healthcare, more effective viricidal or antiviral therapies must be developed. The need to find safe, novel, and effective alternatives against viral diseases is heightened by the rapid emergence of resistance to, and the high cost of, synthetic antiviral drug(s). The development of novel multi-target antiviral compounds that affect multiple steps of the viral life cycle and host proteins has benefited tremendously from looking to nature for guidance and inspiration. Hundreds of natural molecules are preferred over synthetic drugs because of concerns regarding efficacy and safety and a high resistance rate to conventional therapies. In addition, naturally occurring antiviral agents have demonstrated reasonable antiviral value in both animal and human studies. Therefore, finding new antiviral drugs is crucial, and natural products provide an excellent opportunity. This brief review examines the evidence of antiviral effects exhibited by various plants and herbs.

Keywords: Flavonoids, viral infection, replication, antiviral, herbs, host proteins.

Graphical Abstract
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