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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Review Article

Inhibition of Interleukin-6 Dependent Metalloproteinases-9/2 Expression in Cancer Cells by Diet Polyphenols

Author(s): Rosaria Arcone*, Rosarita Nasso, Valentina Pagliara, Antonio D'Errico, Maria Letizia Motti, Stefania D'Angelo, Gabriele Carbonara and Mariorosario Masullo*

Volume 22, Issue 1, 2023

Published on: 09 August, 2023

Page: [30 - 41] Pages: 12

DOI: 10.2174/1871523022666230718113806

Price: $65


Among inflammatory cytokines, Interleukin-6 (IL-6) is one of the major activators of acute phase response and is also involved in immune response and cancer progression. IL-6 is involved in the up-regulation of enzymes and growth factors acting on the extracellular matrix (ECM) remodelling components in physio-pathological processes. IL-6 enhances the expression of metalloproteases (MMP-)2/9, enzymes that play a key role in ECM degradation and therefore contribute to the process of tumor metastasis. To counteract and/or prevent cancer diseases, many efforts have been devoted to the identification of factors able to inhibit the IL-6-dependent MMP-9/2 expression. Recently, diet polyphenols have been identified as molecules manifesting anti-inflammatory and anti-cancer properties beyond their well-known capacity to promote health on the basis of their antioxidant effects. This review summarizes the recent advances in this field, focusing on the protective effects exerted by diet polyphenols on the proliferation and invasiveness of tumor cells, with specific emphasis on the ability of these molecules to inhibit the IL-6-dependent upregulation of MMP-2/9.

Keywords: Interleukin-6 (IL-6), matrix metalloproteases (MMP-)2/9, tumor cell microenvironment, diet polyphenols, anticancer prevention molecules, immune response.

Graphical Abstract
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