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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Mini-Review Article

An Update on Herbal Products for the Management of Inflammatory Bowel Disease

Author(s): Himanshu Arya, Rameshwar Dass, Bhawna Chopra, Priyanka Kriplani, Geeta Deswal, Ajmer Singh Grewal, Ashwani K. Dhingra* and Suresh Kumar

Volume 22, Issue 1, 2023

Published on: 18 August, 2023

Page: [1 - 9] Pages: 9

DOI: 10.2174/1871523022666230727094250

Price: $65


Inflammatory Bowel Disease (IBD), including Ulcerative Colitis (UC) and Crohn's Disease (CD), is a continuously increasing healthcare problem mainly characterized by chronic relapsing intestinal inflammation. The common symptoms of UC and CD include inflammation, diarrhea, abdominal pain, bleeding, and weight loss. IBD is generally caused by an interaction between genetic and environmental or microbial factors that influence the body's immune response and is responsible for digestive disorders and inflammation of the intestinal tract. However, a complete understanding of the pathophysiology and work-up of IBD is necessary to ensure appropriate treatment for the management of this complex disease. This review enlightens herbal therapeutics and drug delivery systems for the management of IBD, and thus provides new insights into this field and facilitates access to new treatments.

Keywords: Inflammatory Bowel Disease (IBD), Crohn’s Disease (CD), Ulcerative Colitis (UC), medicinal plants, IBD treatment, digestive disorder.

Graphical Abstract
Ahmed, W.; Katz, S. Therapeutic use of cannabis in inflammatory bowel disease. Gastroenterol. Hepatol., 2016, 12(11), 668-679.
[PMID: 28035196]
Enck, P.; Aziz, Q.; Barbara, G.; Farmer, A.D.; Fukudo, S.; Mayer, E.A.; Niesler, B.; Quigley, E.M.M.; Rajilić-Stojanović, M.; Schemann, M.; Schwille-Kiuntke, J.; Simren, M.; Zipfel, S.; Spiller, R.C. Irritable bowel syndrome. Nat. Rev. Dis. Primers, 2016, 2(1), 16014.
[] [PMID: 27159638]
Saha, L. Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine. World J. Gastroenterol., 2014, 20(22), 6759-6773.
[] [PMID: 24944467]
Canavan, C.; Abrams, K.R.; Mayberry, J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease. Aliment. Pharmacol. Ther., 2006, 23(8), 1097-1104.
[] [PMID: 16611269]
Fakhoury, M.; Al-Salami, H.; Negrulj, R.; Mooranian, A. Inflammatory bowel disease: clinical aspects and treatments. J. Inflamm. Res., 2014, 7, 113-120.
[] [PMID: 25075198]
Rahimi, R.; Shams-Ardekani, M.R.; Abdollahi, M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J. Gastroenterol., 2010, 16(36), 4504-4514.
[] [PMID: 20857519]
Tanaka, S.; Mitsui, K.; Shirakawa, K.; Tatsuguchi, A.; Nakamura, T.; Hayashi, Y.; Jakazoe, M.; Sakamoto, C.; Terano, A. Successful retrieval of video capsule endoscopy retained at ileal stenosis of Crohn’s disease using double-balloon endoscopy. J. Gastroenterol. Hepatol., 2006, 21(5), 922-923.
[] [PMID: 16704551]
Hruz, P.; Eckmann, L. Innate immune defence: NOD2 and autophagy in the pathogenesis of Crohn’s disease. Swiss Med. Wkly., 2010, 140, w13135.
[] [PMID: 21213148]
Lee, K.J. Pharmacologic agents for chronic diarrhea. Intest. Res., 2015, 13(4), 306-312.
[] [PMID: 26576135]
Agunu, A.; Yusuf, S.; Andrew, G.O.; Zezi, A.U.; Abdurahman, E.M. Evaluation of five medicinal plants used in diarrhoea treatment in Nigeria. J. Ethnopharmacol., 2005, 101(1-3), 27-30.
[] [PMID: 15908152]
Iizuka, N.; Hamamoto, Y. Constipation and herbal medicine. Front. Pharmacol., 2015, 6, 73.
[] [PMID: 25904866]
Vasas, A.; Orbán-Gyapai, O.; Hohmann, J. The Genus Rumex: Review of traditional uses, phytochemistry and pharmacology. J. Ethnopharmacol., 2015, 175, 198-228.
[] [PMID: 26384001]
Basit, A.W. Advances in colonic drug delivery. Drugs, 2005, 65(14), 1991-2007.
[] [PMID: 16162022]
Lamprecht, A.; Ubrich, N.; Hombreiro Pérez, M.; Lehr, C.M.; Hoffman, M.; Maincent, P. Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification. Int. J. Pharm., 1999, 184(1), 97-105.
[] [PMID: 10425355]
Goldman, P. Herbal medicines today and the roots of modern pharmacology. Ann. Intern. Med., 2001, 135(8_Part_1), 594-600.
[] [PMID: 11601931]
Kulkarni, G.T. Herbal drug delivery systems: An emerging area in herbal drug research. J. Chronother. Drug Deliv., 2011, 2(3), 113-119.
Charman, W.N.; Chan, H.K.; Finnin, B.C.; Charman, S.A. Drug delivery: A key factor in realising the full therapeutic potential of drugs. Drug Dev. Res., 1999, 46(3-4), 316-327.
Langmead, L.; Makins, R.J.; Rampton, D.S. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment. Pharmacol. Ther., 2004, 19(5), 521-527.
[] [PMID: 14987320]
Salem, M.B.; Affes, H.; Ksouda, K.; Dhouibi, R.; Sahnoun, Z.; Hammami, S.; Zeghal, K.M. Pharmacological studies of artichoke leaf extract and their health benefits. Plant Foods Hum. Nutr., 2015, 70(4), 441-453.
[] [PMID: 26310198]
Al-Snafi, A.E. Constituents and pharmacology of fumaria officinalisa review. IOSR J. Pharm., 2020, 10(1), 17-25.
Ganeshpurkar, A.; Saluja, A.K. The pharmacological potential of rutin. Saudi Pharm. J., 2017, 25(2), 149-164.
[] [PMID: 28344465]
Basson, A.R.; Ahmed, S.; Almutairi, R.; Seo, B.; Cominelli, F. Regulation of intestinal inflammation by soybean and soy-derived compounds. Foods, 2021, 10(4), 774.
[] [PMID: 33916612]
Parkinson, L.; Keast, R. Oleocanthal, a phenolic derived from virgin olive oil: A review of the beneficial effects on inflammatory disease. Int. J. Mol. Sci., 2014, 15(7), 12323-12334.
[] [PMID: 25019344]
Govindarajan, V.S.; Stahl, W.H. Turmeric — chemistry, technology, and quality. CRC Crit. Rev. Food Sci. Nutr., 1980, 12(3), 199-301.
[] [PMID: 6993103]
Burge, K.; Gunasekaran, A.; Eckert, J.; Chaaban, H. Curcumin and intestinal inflammatory diseases: Molecular mechanisms of protection. Int. J. Mol. Sci., 2019, 20(8), 1912.
[] [PMID: 31003422]
Galiniak, S.; Aebisher, D.; Bartusik-Aebisher, D. Health benefits of resveratrol administration. Acta Biochim. Pol., 2019, 66(1), 13-21.
[PMID: 30816367]
Sanders, T.H.; McMichael, R.W., Jr; Hendrix, K.W. Occurrence of resveratrol in edible peanuts. J. Agric. Food Chem., 2000, 48(4), 1243-1246.
[] [PMID: 10775379]
Shrikanta, A.; Kumar, A.; Govindaswamy, V. Resveratrol content and antioxidant properties of underutilized fruits. J. Food Sci. Technol., 2015, 52(1), 383-390.
[] [PMID: 25593373]
Dong, Q.; Li, Z.; Zhang, Q.; Hu, Y.; Liang, H.; Xiong, L. Astragalus mongholicus bunge (Fabaceae): Bioactive compounds and potential therapeutic mechanisms against alzheimer’s disease. Front. Pharmacol., 2022, 13, 924429.
[] [PMID: 35837291]
Dong, J.; Liang, W.; Wang, T.; Sui, J.; Wang, J.; Deng, Z.; Chen, D. Saponins regulate intestinal inflammation in colon cancer and IBD. Pharmacol. Res., 2019, 144, 66-72.
[] [PMID: 30959159]
Campmans-Kuijpers, M.J.E.; Dijkstra, G.; Gerard, D. Food and food groups in inflammatory bowel disease (IBD): The design of the groningen anti-inflammatory diet (GrAID). Nutrients, 2021, 13(4), 1067.
[] [PMID: 33806061]
Sandborn, W.J.; Targan, S.R.; Byers, V.S.; Rutty, D.A.; Mu, H.; Zhang, X.; Tang, T. Andrographis paniculata extract (HMPL-004) for active ulcerative colitis. Am. J. Gastroenterol., 2013, 108(1), 90-98.
[] [PMID: 23044768]
Triantafyllidi, A.; Xanthos, T.; Papalois, A.; Triantafillidis, J.K. Herbal and plant therapy in patients with inflammatory bowel disease. Ann. Gastroenterol., 2015, 28(2), 210-220.
[PMID: 25830661]
Siddiqui, M.Z. Boswellia serrata, a potential antiinflammatory agent: An overview. Indian J. Pharm. Sci., 2011, 73(3), 255-261.
[PMID: 22457547]
Huber, R.; Ditfurth, A.; Amann, F.; Güthlin, C.; Rostock, M.; Trittler, R.; Kümmerer, K.; Merfort, I. Tormentil for active ulcerative colitis: An open-label, dose-escalating study. J. Clin. Gastroenterol., 2007, 41(9), 834-838.
[] [PMID: 17881930]
Biedermann, L.; Mwinyi, J.; Scharl, M.; Frei, P.; Zeitz, J.; Kullak-Ublick, G.A.; Vavricka, S.R.; Fried, M.; Weber, A.; Humpf, H.U.; Peschke, S.; Jetter, A.; Krammer, G.; Rogler, G. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis — An open pilot study. J. Crohn’s Colitis, 2013, 7(4), 271-279.
[] [PMID: 22883440]
Chen, M.; Ding, Y.; Tong, Z. Efficacy and safety of Sophora flavescens (Kushen) based traditional chinese medicine in the treatment of ulcerative colitis: Clinical evidence and potential mechanisms. Front. Pharmacol., 2020, 11, 603476.
[] [PMID: 33362558]
Yasueda, A.; Kayama, H.; Murohashi, M.; Nishimura, J.; Wakame, K.; Komatsu, K.; Ogino, T.; Miyoshi, N.; Takahashi, H.; Uemura, M.; Matsuda, C.; Kitagawa, T.; Takeda, K.; Ito, T.; Doki, Y.; Eguchi, H.; Shimizu, S.; Mizushima, T. Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages. Sci. Rep., 2020, 10(1), 9972.
[] [PMID: 32561763]
Naganuma, M. Treatment with indigo naturalis for inflammatory bowel disease and other immune diseases. Immunol. Med., 2019, 42(1), 16-21.
[] [PMID: 31034341]
Kawaguchi, S.; Sakuraba, H.; Kikuchi, H.; Matsuki, K.; Hayashi, Y.; Ding, J.; Tanaka, Y.; Seya, K.; Matsumiya, T.; Hiraga, H.; Fukuda, S.; Sasaki, K.; Imaizumi, T. Polygonum tinctorium leaf extract ameliorates high-fat diet-induced intestinal epithelial damage in mice. Exp. Ther. Med., 2023, 25(3), 112.
[] [PMID: 36793327]
Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M.B.P.P. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytother. Res., 2018, 32(12), 2323-2339.
[] [PMID: 30117204]
Lu, Q.; Wu, X.; Han, W.; Zhang, W.; Wang, Y.; Kong, D.; Fan, Z. Effect of Glycyrrhiza uralensis against ulcerative colitis through regulating the signaling pathway of FXR/P-gp. Am. J. Transl. Res., 2021, 13(8), 9296-9305.
[PMID: 34540046]
Hasenoehrl, C.; Storr, M.; Schicho, R. Cannabinoids for treating inflammatory bowel diseases: Where are we and where do we go? Expert Rev. Gastroenterol. Hepatol., 2017, 11(4), 329-337.
[] [PMID: 28276820]
Wu, X.X.; Huang, X.L.; Chen, R.R.; Li, T.; Ye, H.J.; Xie, W.; Huang, Z.M.; Cao, G.Z. Paeoniflorin prevents intestinal barrier disruption and inhibits Lipopolysaccharide (LPS)-induced inflammation in Caco-2 cell monolayers. Inflammation, 2019, 42(6), 2215-2225.
[] [PMID: 31473900]
Lashgari, N.A.; Momeni Roudsari, N.; Khayatan, D.; Shayan, M.; Momtaz, S.; Roufogalis, B.D.; Abdolghaffari, A.H.; Sahebkar, A. Ginger and its constituents: Role in treatment of inflammatory bowel disease. Biofactors, 2022, 48(1), 7-21.
[] [PMID: 34882874]
Valido, E.; Stoyanov, J.; Bertolo, A.; Hertig-Godeschalk, A.; Zeh, R.M.; Flueck, J.L.; Minder, B.; Stojic, S.; Metzger, B.; Bussler, W.; Muka, T.; Kern, H.; Glisic, M. Systematic review of the effects of oat intake on Gastrointestinal Health. J. Nutr., 2021, 151(10), 3075-3090.
[] [PMID: 34486656]
Wu, B.; Zhou, Q.; He, Z.; Wang, X.; Sun, X.; Chen, Y. Protective effect of the Abelmoschus manihot flower extract on DSS-Induced ulcerative colitis in mice. Evid. Based Complement. Alternat. Med., 2021, 2021, 1-12.
[] [PMID: 34408782]
Zhang, W.; Cheng, C.; Han, Q.; Chen, Y.; Guo, J.; Wu, Q.; Zhu, B.; Shan, J.; Shi, L. Flos Abelmoschus manihot extract attenuates DSS-induced colitis by regulating gut microbiota and Th17/Treg balance. Biomed. Pharmacother., 2019, 117, 109162.
[] [PMID: 31254739]
Kim, T.W.; Shin, J.S.; Chung, K.S.; Lee, Y.G.; Baek, N.I.; Lee, K.T. Anti-inflammatory mechanisms of koreanaside a, a lignan isolated from the flower of forsythia koreana, against LPS-induced macrophage activation and DSS-induced colitis mice: The crucial role of AP-1, NF-κB, and JAK/STAT signaling. Cells, 2019, 8(10), 1163.
[] [PMID: 31569788]
Hossen, I.; Hua, W.; Ting, L.; Mehmood, A.; Jingyi, S.; Duoxia, X.; Yanping, C.; Hongqing, W.; Zhipeng, G.; Kaiqi, Z.; Fang, Y.; Junsong, X. Phytochemicals and inflammatory bowel disease: a review. Crit. Rev. Food Sci. Nutr., 2020, 60(8), 1321-1345.
[] [PMID: 30729797]
Zhang, D.K.; Yu, J.J.; Li, Y.M.; Wei, L.N.; Yu, Y.; Feng, Y.H.; Wang, X. A Picrorhiza kurroa derivative, picroliv, attenuates the development of dextran-sulfate-sodium-induced colitis in mice. Mediators Inflamm., 2012, 2012, 1-9.
[] [PMID: 23125487]
Wang, D.; Zhou, L.; Zhou, H.; Hou, G. Effects of Guava (Psidium guajava L.) Leaf Extract on the metabolomics of serum and feces in weaned piglets challenged by Escherichia coli. Front. Vet. Sci., 2021, 8, 656179.
[] [PMID: 34109234]
Liang, J.; Liang, J.; Hao, H.; Lin, H.; Wang, P.; Wu, Y.; Jiang, X.; Fu, C.; Li, Q.; Ding, P.; Liu, H.; Xiong, Q.; Lai, X.; Zhou, L.; Chan, S.; Hou, S. Corrigendum: The Extracts of Morinda officinalis and its hairy roots attenuate dextran sodium sulfate-induced chronic ulcerative colitis in mice by regulating inflammation and lymphocyte apoptosis. Front. Immunol., 2020, 11, 2092.
[] [PMID: 33042122]
Weber, L.; Hammoud Mahdi, D.; Jankuhn, S.; Lipowicz, B.; Vissiennon, C. Bioactive plant compounds in coffee charcoal (Coffeae carbo) Extract inhibit cytokine release from activated human THP-1 macrophages. Molecules, 2019, 24(23), 4263.
[] [PMID: 31766780]
Wang, J.; Wang, X.; Ma, X.; Xu, B.; Chen, L.; Chen, C.; Liu, W.; Liu, Y.; Xiang, Z. Therapeutic effect of Patrinia villosa on TNBS-induced ulcerative colitis via metabolism, vitamin D receptor and NF-κB signaling pathways. J. Ethnopharmacol., 2022, 288, 114989.
[] [PMID: 35032589]
Jang, J.Y.; Im, E.; Kim, N.D. Therapeutic potential of bioactive components from Scutellaria baicalensis Georgi in inflammatory bowel disease and colorectal cancer: A review. Int. J. Mol. Sci., 2023, 24(3), 1954.
[] [PMID: 36768278]
Mathew, N.S.; Muthukumar, S.P.; Bettadaiah, B.K.; Negi, P.S. Efficacy of a functional food ingredient from Ensete superbum Roxb. Cheesman peel in reducing the severity of ulcerative colitis in a murine model. Food Funct., 2022, 13(6), 3732-3745.
[] [PMID: 35266931]
Mohammed, M.A.; Ibrahim, B.M.M.; Abdel-Latif, Y.; Hassan, A.H.; El Raey, M.A.; Hassan, E.M.; El-Gengaihi, S.E. Pharmacological and metabolomic profiles of Musa acuminata wastes as a new potential source of anti-ulcerative colitis agents. Sci. Rep., 2022, 12(1), 10595.
[] [PMID: 35732649]
Khan, M.G. Topic–the novel drug delivery system. World J. Pharm. Pharm. Sci., 2017, 13, 477-487.
Sarangi, M.K.; Padhi, S. Novel herbal drug delivery system: An overview. Arch. Med. Sci., 2018, 6(1), 171.
Jain, N.; Valli, K.S.; Devi, V.K. Importance of novel drug delivery systems in herbal medicines. Pharmacogn. Rev., 2010, 4(7), 27-31.
[] [PMID: 22228938]
Osweiler, G.D.; Carson, T.L.; Buck, W.B.; Van Gelder, G.A. Clinical and diagnostic veterinary toxicology; Kendall Hunt Publishing Company: Dubuque, 1985.
Wirtz, S.; Neufert, C.; Weigmann, B.; Neurath, M.F. Chemically induced mouse models of intestinal inflammation. Nat. Protoc., 2007, 2(3), 541-546.
[] [PMID: 17406617]
Canny, G.O.; McCormick, B.A. Bacteria in the intestine, helpful residents or enemies from within? Infect. Immun., 2008, 76(8), 3360-3373.
[] [PMID: 18474643]
Mehta, T.J.; Patel, A.D.; Patel, M.R.; Patel, N.M. Need of colon specific drug delivery system: review on primary and novel approaches. IJPRD, 2011, 3(1), 134-153.
Sharma, N.S.; Harikumar, S.L. Polymers for colon targeted drug delivery: a review. Int. J. Drug Dev. Res., 2013, 5(1), 21-31.
Pandurangan, A.K.; Mohebali, N.; Esa, N.M.; Looi, C.Y.; Ismail, S.; Saadatdoust, Z. Gallic acid suppresses inflammation in dextran sodium sulfate-induced colitis in mice: Possible mechanisms. Int. Immunopharmacol., 2015, 28(2), 1034-1043.
[] [PMID: 26319951]
Dar, M.J.; Ali, H.; Khan, A.; Khan, G.M. Polymer-based drug delivery: The quest for local targeting of inflamed intestinal mucosa. J. Drug Target., 2017, 25(7), 582-596.
[] [PMID: 28277824]
Nishida, A.; Inoue, R.; Inatomi, O.; Bamba, S.; Naito, Y.; Andoh, A. Gut microbiota in the pathogenesis of inflammatory bowel disease. Clin. J. Gastroenterol., 2018, 11(1), 1-10.
[] [PMID: 29285689]
Guan, Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J. Immunol. Res., 2019, 2019, 1-16.
[] [PMID: 31886308]
Tamilarasan, A.G.; Cunningham, G.; Irving, P.M.; Samaan, M.A. Recent advances in monoclonal antibody therapy in IBD: Practical issues. Frontline Gastroenterol., 2019, 10(4), 409-416.
[] [PMID: 31656567]
Muchtaridi, M.; Belali, N.; Wathoni, N. Advances in orally targeted drug delivery to colon. J. Adv. Pharm. Technol. Res., 2019, 10(3), 100-106.
[] [PMID: 31334090]
Porter, R.J.; Kalla, R.; Ho, G.T. Ulcerative colitis: Recent advances in the understanding of disease pathogenesis. F1000 Res., 2020, 9, 294.
Lee, S.H.; Bajracharya, R.; Min, J.Y.; Han, J.W.; Park, B.J.; Han, H.K. Strategic approaches for colon targeted drug delivery: An overview of recent advancements. Pharmaceutics, 2020, 12(1), 68.
[] [PMID: 31952340]
Bayan, M.F.; Bayan, R.F. Recent advances in mesalamine colonic delivery systems. Future Journal of Pharmaceutical Sciences, 2020, 6(1), 43.
Naeem, M.; Awan, U.A.; Subhan, F.; Cao, J.; Hlaing, S.P.; Lee, J.; Im, E.; Jung, Y.; Yoo, J.W. Advances in colon-targeted nano-drug delivery systems: Challenges and solutions. Arch. Pharm. Res., 2020, 43(1), 153-169.
[] [PMID: 31989477]
Khalid, M.; Alqarni, M.H.; Shoaib, A.; Arif, M.; Foudah, A.I.; Afzal, O.; Ali, A.; Ali, A.; Alqahtani, S.S.; Altamimi, A.S.A. Anti-arthritic and anti-inflammatory potential of Spondias mangifera Extract Fractions: An In silico, In vitro and In vivo approach. Plants, 2021, 10(5), 825.
[] [PMID: 33919084]
Vemula, S.K.; Bontha, V.K. Colon targeted guar gum compression coated tablets of flurbiprofen: formulation, development, and pharmacokinetics. BioMed Res. Int., 2013, 2013, 1-8.
[] [PMID: 24260738]
Badhana, S.; Garud, N.; Garud, A. Colon specific drug delivery of mesalamine using eudragit S100-coated chitosan microspheres for the treatment of ulcerative colitis. Int. Curr. Pharm. J., 2013, 2(3), 42-48.
Chandra, D.; Yadav, I.K.; Singh, H.P.; Jain, D.A. Design and development of satranidazole microspheres for colon targeted drug delivery. Int. J. Pharm. Chem. Sci., 2012, 1(3), 1161-1167.
Najmuddin, M.; Patel, V.; Ahmed, A.; Shelar, S.; Khan, T. Preparation and evaluation of Flurbiprofen microcapsule for colonic drug delivery system. Int. J. Pharm. Pharm., 2010, 2(2), 83-87.
Agarwal, D.; Ranawat, M.S.; Chauhan, C.S.; Kamble, R. Formulation and charecterisation of colon targeted ph dependent microspheres of capecitabine for colorectal canceR. J. Drug Deliv. Ther., 2013, 3(6), 215-222.
Kumar, S.; Parthiban, S.; Kumar, S.S. Formulation and evaluation of meloxicam loaded microspheres for colon targeted drug delivery. AJPCR, 2013, 4(2), 80-89.
Sb, A.; Parthiban, S.; Senthil Kumar, G.P.; Tamizh Mani, T. Microparticle as suitable drug carriers for colon targeting - a recent review OSC. American J. PharmTech. Res., 2018, 8(1), 44-57.
Kalla, M.; Rani, S.S.; Zahra, F. Formulation and in vitro evaluation of piroxicam loaded alginate microspheres (Colon Specific) using ionotropic gelation technique. IOSR J. Pharm., 2016, 6(3), 23-28.

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