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Current Molecular Pharmacology


ISSN (Print): 1874-4672
ISSN (Online): 1874-4702


Ketamine Metabolites-waiting in the Wings as Therapeutic Candidate for Depression?

Author(s): Ming Tatt Lee and Yu-Cheng Ho*

Volume 17, 2024

Published on: 04 September, 2023

Article ID: e080823219541 Pages: 2

DOI: 10.2174/1874467217666230808162402

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Li, Y.; Du, Y.; Wang, C.; Lu, G.; Sun, H.; Kong, Y.; Wang, W.; Lian, B.; Li, C.; Wang, L.; Zhang, X.; Sun, L. (2R,6R)-hydroxynorketamine acts through GluA1-induced synaptic plasticity to alleviate PTSD-like effects in rat models. Neurobiol. Stress, 2022, 21, 100503.
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Xiong, Z.; Fujita, Y.; Zhang, K.; Pu, Y.; Chang, L.; Ma, M.; Chen, J.; Hashimoto, K. Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model. Behav. Brain Res., 2019, 368, 111904.
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