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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Mini-Review Article

Pyrazine Moiety: Recent Developments in Cancer Treatment

Author(s): Rakesh Sahu*, Kamal Shah, Yash Gautam and Kaushilya Sahu

Volume 27, Issue 10, 2023

Published on: 31 August, 2023

Page: [821 - 843] Pages: 23

DOI: 10.2174/1385272827666230816105317

Price: $65


Cancer is becoming more common worldwide, impacting the vast majority of people. As a result, new anticancer drugs are currently being created, and their safety is still being assessed. Pyrazine-based medications are a substantial contribution, as they are one of the most important pharmacophores found in heterocyclic compounds both synthetically and naturally. It's a six-membered aromatic heterocycle with two nitrogen atoms with a wide range of therapeutic applications in drug development and numerous prospects for future enhancement in anticancer drugs by targeting several critical receptors. A number of pyrazine compounds have been shown to inhibit enzymes, receptors, and a range of additional cancer-fighting targets. Researchers are currently focused on the creation of pyrazine-based novel derivatives for cancer treatment in combination with other moieties. As a result, this review illuminates the recent therapeutic expansion of pyrazine-based drugs, as well as their synthetic schemes, tabulated detailed clinical trial drugs, marketed drugs with their primary target, and a list of recently patented and published research papers, all of which will help scientists build successful medications with the appropriate pharmacological activity.

Keywords: Pyrazine moiety, heterocyclic compound, synthetic scheme, anticancer, cancer treatment, pyrazine-based drugs.

Graphical Abstract
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