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Review Article

A Comprehensive Review on Therapeutic Potential of a Natural Anthraquinone Derivative Emodin in Brain-related Disorders

Author(s): Ahsas Goyal, Yogesh Murti*, Bharat Bhushan, Wasim Chisti and Ashutosh Solanki

Volume 24, Issue 12, 2023

Published on: 31 August, 2023

Page: [945 - 958] Pages: 14

DOI: 10.2174/1389450124666230818092506

Price: $65

Abstract

Brain-related disorders are one of the world’s most important and complex health problems today. These brain-related disorders are responsible for a massive number of morbidities and death all around the world. However, researchers have devoted a large amount of time to investigating these diseases and found positive results; nevertheless, there are currently quite a few medications available to treat them. Emodin (EM), a polyphenol compound, has many health benefits. It is a biologically active monomer derived from rhubarb root that exhibits anti-inflammation, anti-oxidation, anticancer, and neuroprotective properties. A series of preclinical trials have shown EM to have protective benefits against many brain-related diseases. This review has evaluated the potential of EM as a pharmacological agent for the treatment and management of various brain-related disorders based on the findings of multiple pre-clinical studies and taking into account the compound’s therapeutic properties.

Keywords: EM, Alzheimer’s disease, parkinson’s disease, stress, epilepsy, depression, cerebral ischemia, glioblastoma, intra-cerebral haemorrhage, traumatic brain injury.

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