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Current Nanomedicine


ISSN (Print): 2468-1873
ISSN (Online): 2468-1881

Research Article

The Tensile Strength of Gelatin Nanofibers Containing Nanohydroxyapatite and Nanocurcumin

Author(s): Yashar Rezaei, Leila Javadikia, Solmaz Maleki Dizaj*, Simin Sharifi* and Amir Reza Jamei Khosroshahi

Volume 13, Issue 3, 2023

Published on: 01 September, 2023

Page: [210 - 216] Pages: 7

DOI: 10.2174/2468187313666230821102705

Price: $65


Aim: The aim of this study was to prepare gelatin-nanocurcumin/nanohydroxy apatite nanofibers and test the effect of nanohydroxyapatite and nanocurcumin on the tensile strength of gelatin nanofibers. Finding the ideal bone replacement material has long been the focus of research in the field of bone regeneration. This study also aimed to assess the effect of adding nanohydroxy-apatite and nanocurcumin on the tensile strength of gelatin nanofibers in order to propose an ideal nanofiberous scaffold for bone regeneration application.

Methods: Gelatin-curcumin nanofibers were prepared using an electrospinning method with a ratio of 70% to 30% of gelatin and curcumin and 5% of hydroxyapatite.

Results: Adding curcumin to the gelatin nanofiber structure increased its tensile strength in the wet state (21.03 ± 2.17 to 28.54 ± 0.59, p < 0.0001). Besides, adding nanohydroxyapatite to the structure of gelatin nanofibers increased its tensile strength in dry (30.31 ± 0.64 to 35.79 ± 1.13, p < 0.0001) and wet conditions (28.54 ± 0.59 to 34.46 ± 0.86, p = 0.0020).

Conclusion: As adding curcumin and nanohydroxyapatite increased the tensile strength of gelatin nanofibers, it seems that these nanofibers can play a promising futuristic role in bone and dental tis-sue engineering. However, more in vitro, in vivo, and clinical studies are recommended to approve this finding.

Keywords: Nanohydroxyapatite, nanocurcumin, tensile strength, gelatin nanofibers, bone regeneration, scaffold.

Graphical Abstract
Elshazli MT, Saras N, Ibrahim A. Structural response of high strength concrete beams using fiber reinforced polymers under reversed cyclic loading. Sustain Struct 2022; 2: 000018.
Ajayan PM, Schadler LS, Braun PV. Nanocomposite science and technology. John Wiley & Sons 2006.
Venkatesan J, Kim SK. Nano-hydroxyapatite composite biomaterials for bone tissue engineering--a review. J Biomed Nanotechnol 2014; 10(10): 3124-40.
[] [PMID: 25992432]
Salem SS. A mini review on green nanotechnology and its development in biological effects. Arch Microbiol 2023; 205(4): 128.
[] [PMID: 36944830]
Poole CP Jr, Owens FJ. Introduction to nanotechnology. John Wiley & Sons 2003.
Mazzola L. Commercializing nanotechnology. Nat Biotechnol 2003; 21(10): 1137-43.
[] [PMID: 14520392]
Feng P, Zhao R, Tang W, et al. Structural and functional adaptive artificial bone: Materials, fabrications, and properties. Adv Funct Mater 2023; 33(23): 2214726.
Abulaiti A, Liu Y, Cai F, et al. Bone defects in Tibia managed by the bifocal vs. trifocal bone transport technique: A retrospective comparative study. Front Surg 2022; 9: 858240.
[] [PMID: 36034365]
Sparks DS, Saifzadeh S, Savi FM, et al. A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction. Nat Protoc 2020; 15(3): 877-924.
[] [PMID: 32060491]
Kim HW, Kim HE, Salih V. Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds. Biomaterials 2005; 26(25): 5221-30.
[] [PMID: 15792549]
Azami M, Samadikuchaksaraei A, Poursamar SA. Synthesis and characterization of a laminated hydroxyapatite/gelatin nanocomposite scaffold with controlled pore structure for bone tissue engineering. Int J Artif Organs 2010; 33(2): 86-95.
[] [PMID: 20306435]
Zadehnajar P, Karbasi S, Akbari B, Mirmusavi MH. Evaluation of physical and mechanical properties of electrospinning nanocomposite scaffolds poly ɛ-caprolactone-gelatin/multi walled carbon nanotube. J Adv Mater Technol 2019; 7(4): 93-100.
Sharifi S, Zaheri Khosroshahi A, Maleki Dizaj S, Rezaei Y. Preparation, physicochemical assessment and the antimicrobial action of hydroxyapatite-gelatin/curcumin nanofibrous composites as a dental biomaterial. Biomimetics 2021; 7(1): 4.
[] [PMID: 35076470]
Samadian H, Zamiri S, Ehterami A, et al. Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: In vitro and in vivo studies. Sci Rep 2020; 10(1): 8312.
[] [PMID: 32433566]
Betz RR. Limitations of autograft and allograft: New synthetic solutions. Orthopedics 2002; 25(5): s561-70.
[] [PMID: 12038843]
Kong YM, Bae CJ, Lee SH, Kim HW, Kim HE. Improvement in biocompatibility of ZrO2-Al2O3 nano-composite by addition of HA. Biomaterials 2005; 26(5): 509-17.
[] [PMID: 15276359]
Kikuchi M, Matsumoto HN, Yamada T, Koyama Y, Takakuda K, Tanaka J. Glutaraldehyde cross-linked hydroxyapatite/collagen self-organized nanocomposites. Biomaterials 2004; 25(1): 63-9.
[] [PMID: 14580909]
Sun J, Gerberich WW, Francis LF. Electrical and optical properties of ceramic-polymer nanocomposite coatings. J Polym Sci, B, Polym Phys 2003; 41(14): 1744-61.
Hayat A, Sohail M, Hamdy MS, et al. Fabrication, characteristics, and applications of boron nitride and their composite nanomaterials. Surf Interfaces 2022; 29: 101725.
Stipniece L, Narkevica I, Sokolova M, Locs J, Ozolins J. Novel scaffolds based on hydroxyapatite/poly(vinyl alcohol) nanocomposite coated porous TiO 2 ceramics for bone tissue engineering. Ceram Int 2016; 42(1): 1530-7.
Kim HW, Knowles JC, Kim HE. Hydroxyapatite and gelatin composite foams processed via novel freeze-drying and crosslinking for use as temporary hard tissue scaffolds. J Biomed Mater Res A 2005; 72A(2): 136-45.
[] [PMID: 15549783]
Yan H, Zhou Z, Huang T, et al. Controlled release in vitro of icariin from gelatin/hyaluronic acid composite microspheres. Polym Bull 2016; 73(4): 1055-66.
Zhou Z, He S, Huang T, et al. Preparation of gelatin/hyaluronic acid microspheres with different morphologies for drug delivery. Polym Bull 2015; 72(4): 713-23.
Damarla SR, Komma R, Bhatnagar U, Rajesh N, Mulla SMA. An evaluation of the genotoxicity and subchronic oral toxicity of synthetic curcumin. J Toxicol 2018; 2018: 6872753.
Ngo HV, Tran PHL, Lee BJ, Tran TTD. Development of film-forming gel containing nanoparticles for transdermal drug delivery. Nanotechnology 2019; 30(41): 415102.
[] [PMID: 31261146]
Shi X, Cui S, Song X, et al. Gelatin-crosslinked pectin nanofiber mats allowing cell infiltration. Mater Sci Eng C 2020; 112: 110941.
[] [PMID: 32409087]
Kim HW, Song JH, Kim HE. Nanofiber generation of gelatin-hydroxyapatite biomimetics for guided tissue regeneration. Adv Funct Mater 2005; 15(12): 1988-94.
Deng L, Li Y, Zhang A, Zhang H. Characterization and physical properties of electrospun gelatin nanofibrous films by incorporation of nano-hydroxyapatite. Food Hydrocoll 2020; 103: 105640.
Lee JB, Kim SE, Heo DN, Kwon IK, Choi BJ. in vitro characterization of nanofibrous PLGA/gelatin/hydroxyapatite composite for bone tissue engineering. Macromol Res 2010; 18(12): 1195-202.
Long H, Ma K, Xiao Z, Ren X, Yang G. Preparation and characteristics of gelatin sponges crosslinked by microbial transglutaminase. PeerJ 2017; 5: e3665.
[] [PMID: 28828260]
Sharifi S, Maleki Dizaj S, Ahmadian E, et al. A biodegradable flexible micro/nano-structured porous hemostatic dental sponge. Nanomaterials 2022; 12(19): 3436.
[] [PMID: 36234564]
Fereydouni N, Movaffagh J, Amiri N, et al. Synthesis of nano-fibers containing nano-curcumin in zein corn protein and its physicochemical and biological characteristics. Sci Rep 2021; 11(1): 1902.
[] [PMID: 33479286]

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