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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Targeting the Tumor Stroma in Cancer Therapy

Author(s): Kevin Anton and John Glod

Volume 10, Issue 2, 2009

Page: [185 - 191] Pages: 7

DOI: 10.2174/138920109787315088

Price: $65


Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions between the stroma and neoplastic cells are largely unexplored. Initial therapies aimed at disrupting angiogenesis within the tumor microenvironment have met with success in a number of tumor types. An improved understanding of stromal signaling pathways is likely to identify additional novel therapeutic targets.

Keywords: Tumor Stroma, Cancer Therapy, neoplastic cells, lymphocytes, vascular cells, angiogenesis

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