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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Apoptosis Pathways and Neuroblastoma Therapy

Author(s): S. Fulda

Volume 15, Issue 4, 2009

Page: [430 - 435] Pages: 6

DOI: 10.2174/138161209787315846

Price: $65


Evasion of apoptosis, the cells intrinsic death program, is a hallmark of human cancers including neuroblastoma. Also, failure to undergo apoptosis may cause treatment resistance, since the cytotoxic activity of anticancer therapies commonly used in the clinic, e.g. chemotherapy, γ-irradiation or immunotherapy, is predominantly mediated by triggering apoptosis in tumor cells. Therefore, a better understanding of the signaling pathways and molecules that govern apoptosis in neuroblastoma cells is expected to open new avenues for the design of molecular targeted therapies for neuroblastoma.

Keywords: Apoptosis, neuroblastoma, TRAIL, caspase-8, Bcl-2, IAPs

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