Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer
Radiotherapy

Fatemeh-Jalali      Zefrei; Mohammd      Shormij; Leila      Dastranj; Maryam      Alvandi; Zahra      Shaghaghi; Soghra      Farzipour; Nasim      Zarei-Polgardani
doi:10.2174/0118744710262369231110065230
Abstract

Radiotherapy (RT) failure has historically been mostly attributed to radioresistance. Ferroptosis is a type of controlled cell death that depends on iron and is caused by polyunsaturated fatty acid peroxidative damage. Utilizing a ferroptosis inducer may be a successful tactic for preventing tumor growth and radiotherapy-induced cell death. A regulated form of cell death known as ferroptosis is caused by the peroxidation of phospholipids containing polyunsaturated fatty acids in an iron-dependent manner (PUFA-PLs). The ferroptosis pathway has a number of important regulators. By regulating the formation of PUFA-PLs, the important lipid metabolism enzyme ACSL4 promotes ferroptosis, whereas SLC7A11 and (glutathione peroxidase 4) GPX4 prevent ferroptosis. In addition to introducing the ferroptosis inducer chemicals that have recently been demonstrated to have a radiosensitizer effect, this review highlights the function and methods by which ferroptosis contributes to RT-induced cell death and tumor suppression in vitro and in vivo.
Keywords: Ferroptosis, radiotherapy, radiosensitizer, radioresistance, cancer, cell death.
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DOI https://dx.doi.org/10.2174/0118744710262369231110065230	Print ISSN 1874-4710
Publisher Name Bentham Science Publisher	Online ISSN 1874-4729
Current Radiopharmaceuticals

Ferroptosis Inducers as Promising Radiosensitizer Agents in Cancer Radiotherapy

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