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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Synthesis of Quinazolines as Tyrosine Kinase Inhibitors

Author(s): Sanjay K. Srivastava, Vivek Kumar, Shiv K. Agarwal, Rama Mukherjee and Anand C. Burman

Volume 9, Issue 3, 2009

Page: [246 - 275] Pages: 30

DOI: 10.2174/1871520610909030246

Price: $65


In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.

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