The Role of Bile Acids in Pancreatic Cancer

Title:The Role of Bile Acids in Pancreatic Cancer

Volume: 24

Author(s): Yanling Wang, Haiyan Xu, Xiaofei Zhang, Jingyu Ma, Shengbai Xue, Daiyuan Shentu, Tiebo Mao, Shumin Li, Ming Yue, Jiujie Cui and Liwei Wang*

Affiliation:

• State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China

Keywords: bile acids, pancreatic cancer, biomarker, carcinogenesis, progression of cancer, chemoresistance

Abstract: Bile acids are well known to promote the digestion and absorption of fat, and at the same time, they play an important role in lipid and glucose metabolism. More studies have found that bile acids such as ursodeoxycholic acid also have anti-inflammatory and immune-regulating effects. Bile acids have been extensively studied in biliary and intestinal tumors but less in pancreatic cancer. Patients with pancreatic cancer, especially pancreatic head cancer, are often accompanied by biliary obstruction and elevated bile acids caused by tumors. Elevated total bile acid levels in pancreatic cancer patients usually have a poor prognosis. There has been controversy over whether elevated bile acids are harmful or beneficial to pancreatic cancer. Still, there is no doubt that bile acids are important for the occurrence and development of pancreatic cancer. This article summarizes the research on bile acid as a biomarker and regulation of the occurrence, development and chemoresistance of pancreatic cancer, hoping to provide some inspiration for future research.

Cite this article as:

Wang Yanling, Xu Haiyan, Zhang Xiaofei, Ma Jingyu, Xue Shengbai, Shentu Daiyuan, Mao Tiebo, Li Shumin, Yue Ming, Cui Jiujie and Wang Liwei*, The Role of Bile Acids in Pancreatic Cancer, Current Cancer Drug Targets 2024; 24 () . https://dx.doi.org/10.2174/0115680096281168231215060301