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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Obstructive Sleep Apnea as an Independent Stroke Risk Factor: Possible Mechanisms

Author(s): Jaime Godoy, Patricio Mellado, Jorge Tapia and Julia Santin

Volume 9, Issue 2, 2009

Page: [203 - 209] Pages: 7

DOI: 10.2174/156652409787581556

Price: $65


Obstructive Sleep Apnea (OSA) is a prevalent disease that has emerged as a new cerebrovascular disease (CVD) risk factor, which is independent of its association to hypertension, age and other known conditions that increase CVD. The mechanisms involved in this relation are most likely induced by the periodic hypoxia/ reoxygenation that characteristically occurs in OSA, which results in oxidative stress, endothelial dysfunction and activation of the inflammatory cascade, all of which favor atherogenesis. Numerous markers of these changes have been reported in OSA patients, including increased circulating free radicals, increased lipid peroxidation, decreased antioxidant capacity, elevation of tumor necrosis factor and interleukines, increased levels of proinflammatory nuclear transcription factor kappa B, decreased circulating nitric oxide, elevation of vascular adhesion molecules and vascular endothelial growth factor. In addition, several authors have described that Continuous Positive Airway Pressure, the standard OSA therapy, reverts these abnormalities. Further research is needed in order to better clarify the complex mechanisms that underlie the relation between OSA, atherogenesis and CVD which most likely will have significant clinical impact.

Keywords: Obstructive Sleep Apnea (OSA), cerebrovascular disease (CVD), risk factor, oxidative stress, tumor necrosis factor

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