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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry


ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Biotechnological Approaches for the Treatment of Inflammatory Diseases

Author(s): V. Iansante, D. Capece, S. Murgo, M. M. Mancarelli, F. Zazzeroni and E. Alesse

Volume 8, Issue 1, 2009

Page: [51 - 71] Pages: 21

DOI: 10.2174/187152309787580793

Price: $65


Chronic inflammation represents a key pathogenetic event of many diseases, such as psoriasis, inflammatory bowel diseases, rheumatoid arthritis, asthma, multiple sclerosis, atherosclerosis, cystic fibrosis, and sepsis. Conventional therapies for many of these disorders do not lead to the resolution of the inflammatory disorder, and frequently are associated with limited effectiveness and severe side effects. For these reasons alternative therapies have been developed, in the attempt to ensure a more sustained therapeutic response. Biotechnological approaches for the development of these novel drugs are giving exciting results: several biologic molecules are now tested in preclinical or clinical trials, and several of them are even approved for marketing.

Keywords: Inflammatory diseases, recombinant proteins, nucleic acid-based therapy

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