Abstract
Background: Colorectal cancer (CRC) ranks among the leading causes of cancerrelated deaths.
Objective: This study aimed to illuminate the relationship between DPP7 (also known as DPP2) and CRC through a combination of bioinformatics and experimental methodologies.
Methods: A multi-dimensional bioinformatic analysis on DPP7 was executed, covering its expression, survival implications, clinical associations, functional roles, immune interactions, and drug sensitivities. Experimental validations involved siRNA-mediated DPP7 knockdown and various cellular assays.
Results: Data from the Cancer Genome Atlas (TCGA) identified high DPP7 expression in solid CRC tumors, with elevated levels adversely affecting patient prognosis. A shift from the N0 to the N2 stage in CRC was associated with increased DPP7 expression. Functional insights indicated the involvement of DPP7 in cancer progression, particularly in extracellular matrix disassembly. Immunological analyses showed its association with immunosuppressive entities, and in vitro experiments in CRC cell lines underscored its oncogenic attributes.
Conclusion: DPP7 could serve as a CRC prognosis marker, functioning as an oncogene and representing a potential immunotherapeutic target.
Keywords: Dipeptidyl Peptidase 7, colorectal cancer, bioinformatics, oncogene, immunotherapy, prognosis.
Combinatorial Chemistry & High Throughput Screening
Title:DPP2/7 is a Potential Predictor of Prognosis and Target in Immunotherapy in Colorectal Cancer: An Integrative Multi-omics Analysis
Volume: 27 Issue: 11
Author(s): Zhihao Shang, Yueyang Lai*Haibo Cheng*
Affiliation:
- The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China
- The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China
Keywords: Dipeptidyl Peptidase 7, colorectal cancer, bioinformatics, oncogene, immunotherapy, prognosis.
Abstract:
Background: Colorectal cancer (CRC) ranks among the leading causes of cancerrelated deaths.
Objective: This study aimed to illuminate the relationship between DPP7 (also known as DPP2) and CRC through a combination of bioinformatics and experimental methodologies.
Methods: A multi-dimensional bioinformatic analysis on DPP7 was executed, covering its expression, survival implications, clinical associations, functional roles, immune interactions, and drug sensitivities. Experimental validations involved siRNA-mediated DPP7 knockdown and various cellular assays.
Results: Data from the Cancer Genome Atlas (TCGA) identified high DPP7 expression in solid CRC tumors, with elevated levels adversely affecting patient prognosis. A shift from the N0 to the N2 stage in CRC was associated with increased DPP7 expression. Functional insights indicated the involvement of DPP7 in cancer progression, particularly in extracellular matrix disassembly. Immunological analyses showed its association with immunosuppressive entities, and in vitro experiments in CRC cell lines underscored its oncogenic attributes.
Conclusion: DPP7 could serve as a CRC prognosis marker, functioning as an oncogene and representing a potential immunotherapeutic target.
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Cite this article as:
Shang Zhihao, Lai Yueyang*, Cheng Haibo*, DPP2/7 is a Potential Predictor of Prognosis and Target in Immunotherapy in Colorectal Cancer: An Integrative Multi-omics Analysis, Combinatorial Chemistry & High Throughput Screening 2024; 27 (11) . https://dx.doi.org/10.2174/0113862073290831240229060932
DOI https://dx.doi.org/10.2174/0113862073290831240229060932 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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