Abstract
p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this review the multifaceted role of p66Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases.
Keywords: p66Shc, oxidative stress, disease, apoptosis
Current Molecular Medicine
Title: Apoptosis and Oxidative Stress-Related Diseases: The p66Shc Connection
Volume: 9 Issue: 3
Author(s): Michela Pellegrini and Cosima T. Baldari
Affiliation:
Keywords: p66Shc, oxidative stress, disease, apoptosis
Abstract: p66Shc is the only known proapoptotic member of the Shc protein family of molecular adaptors. Through its redox activity, p66Shc oxidates cytochrome-c, leading to increased ROS production and, eventually, to apoptosis. p66Shc has been implicated in the control of oxidative stress and life span in mammals. In this review the multifaceted role of p66Shc in redox regulation will be discussed, with a focus on the mechanisms underlying p66Shc-dependent apoptosis and its role in oxidative stress-related diseases.
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Cite this article as:
Pellegrini Michela and Baldari T. Cosima, Apoptosis and Oxidative Stress-Related Diseases: The p66Shc Connection, Current Molecular Medicine 2009; 9 (3) . https://dx.doi.org/10.2174/156652409787847254
DOI https://dx.doi.org/10.2174/156652409787847254 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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