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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies

Author(s): Aude-Helene Capietto, Samarh Keirallah, Emilie Gross, Nicolas Dauguet, Emilie Laprevotte, Christine Jean, Julie Gertner-Dardenne, Christine Bezombes, Anne Quillet-Mary, Mary Poupot, Loic Ysebaert, Guy Laurent and Jean-Jacques Fournie

Volume 11, Issue 7, 2010

Page: [790 - 800] Pages: 11

DOI: 10.2174/138945010791320845

Price: $65


The development of therapeutic monoclonal antibodies (mAbs) has revolutionized the treatment of cancer along the last ten years. The best examples of their therapeutic efficacies have been obtained with rituximab for the treatment of CD20+ B-cell Non-Hodgkin Lymphoma (B-NHL), and several others antibodies with optimized bioactivities are now being developed for the treatment of various malignant hemopathies. We review here the main drugs developed in this field, and present some emerging concepts able to improve the bioactivities of the next generation of therapeutic mAbs.

Keywords: Cancer, lymphoma, therapy, antibodies, phosphoantigens

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