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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

The Control of Endoplasmic Reticulum-Initiated Apoptosis by the BCL-2 Family of Proteins

Author(s): Scott A. Oakes, Stephen S. Lin and Michael C. Bassik

Volume 6, Issue 1, 2006

Page: [99 - 109] Pages: 11

DOI: 10.2174/156652406775574587

Price: $65


Irreversible perturbations in the homeostasis of the endoplasmic reticulum (ER) are thought to lead to apoptosis and cell loss in a number of important human diseases, including Alzheimer disease, Parkinson disease, and type 2 diabetes. However, the exact mechanisms that lead from ER stress to cell death remain incompletely understood. Recent work has shown that the BCL-2 family of proteins plays a central role in regulating this form of cell death, both locally at the ER and from a distance at the mitochondrial membrane.

Keywords: BH4-domain, mitochondrion, Homeostasis, Cell Death, IP3 Receptor, transcription factor, NOXA expression

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