Abstract
The cytotoxic activities of a series of HEPT analogues were modeled using 1x, Vw, Xeq along with indicator parameters. Based on the dominance of electro-negativity the data set of 59 compounds has to be divided into two subsets consisting of 48 and 11 compounds respectively. The latter subset was dominated by electronegativity effect (Xeq). Excellent results are obtained in multi-parametric regressions and are discussed critically.
Keywords: Cytotoxic activity, HEPT, van der Waals volume, equalized electro-negativity, molecular connectivity, regression analysis
Letters in Drug Design & Discovery
Title: QSAR Study on Cytotoxic Activities of a Series of HEPT Analogues
Volume: 3 Issue: 2
Author(s): Vijay K. Agrawal, Jyoti Singh, K. C. Mishra and Padmakar V. Khadikar
Affiliation:
Keywords: Cytotoxic activity, HEPT, van der Waals volume, equalized electro-negativity, molecular connectivity, regression analysis
Abstract: The cytotoxic activities of a series of HEPT analogues were modeled using 1x, Vw, Xeq along with indicator parameters. Based on the dominance of electro-negativity the data set of 59 compounds has to be divided into two subsets consisting of 48 and 11 compounds respectively. The latter subset was dominated by electronegativity effect (Xeq). Excellent results are obtained in multi-parametric regressions and are discussed critically.
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Cite this article as:
Agrawal K. Vijay, Singh Jyoti, Mishra C. K. and Khadikar V. Padmakar, QSAR Study on Cytotoxic Activities of a Series of HEPT Analogues, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789775
DOI https://dx.doi.org/10.2174/157018006775789775 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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