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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Antiviral Sensing in Teleost Fish

Author(s): Jun Zou, Steve Bird and Chris Secombes

Volume 16, Issue 38, 2010

Page: [4185 - 4193] Pages: 9

DOI: 10.2174/138161210794519093

Price: $65


Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.

Keywords: Pattern recognition, Toll like receptors, RIG-I like receptor, protein kinase R, teleost fish

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