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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Targeting Proteasomes with Naturally Occurring Compounds in Cancer Treatment

Author(s): V. Cecarini, M. Cuccioloni, M. Mozzicafreddo, L. Bonfili, M. Angeletti and A. M. Eleuteri

Volume 11, Issue 3, 2011

Page: [307 - 324] Pages: 18

DOI: 10.2174/156800911794519815

Price: $65


Aberrant cellular proliferation and compromised apoptotic pathways are hallmarks of cancer aggressiveness, and in this framework, the role of protein degradation machineries have been extensively dissected. Among proteases, the proteasome is unequivocally central in the intracellular regulation of both these processes, thus several proteasome-directed therapies have been investigated, aiming at controlling its activity and possibly restoring normal cell functions. Numerous studies reported proteasome inhibitors (both synthetic and natural occurring) to potently and selectively induce apoptosis in many types of cancer cells. In this review, we discuss recent advances in proteasomal modulation by some natural occurring polyphenols, globally providing evidence of the proteasome role as therapeutic target in cancer treatment.

Keywords: Apoptosis, cancer, polyphenols, proteasome

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