Abstract
Diabetes is a chronic metabolic disorder that continues to present as a major health problem worldwide. It is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action and is associated with chronic hyperglycemia and disturbances of carbohydrate, lipid, and protein metabolism. Many studies suggest a central role for oxidative stress in the pathogenesis of this multi-faceted metabolic disorder. This has prompted investigations in the use of antioxidants as a complementary therapeutic approach. In this review we briefly summarize oxidative mechanisms implicated in diabetic complications and then focus on the findings resulting from human clinical trials where antioxidants were studied as an adjuvant to standard diabetes treatment during the last ten years. A literature search using PubMed (last ten years) was performed using the following terms: vitamin E, vitamin C, coenzyme Q10, alpha lipoic acid, L-carnitine, ruboxistaurin or LY 333531 and diabetes. This search was limited to human clinical trials. We conclude there is not any established benefit for antioxidant use in the management of diabetic complications. Therefore, routine vitamin or mineral supplementation is not generally recommended in human diabetes.
Keywords: Anti-Oxidants, Diabetes, Oxidative Stress, Chronic Metabolic Disorder, Insulin, Vitamin E, Vitamin C, Coenzyme Q10, Alpha Lipoic Acid, L-Carnitine, Reactive Oxygen Species, Antioxidants in the Treatment of Diabetes, Antioxidants
Current Diabetes Reviews
Title: Antioxidants in the Treatment of Diabetes
Volume: 7 Issue: 2
Author(s): Saeid Golbidi, S. Alireza Ebadi and Ismail Laher
Affiliation:
Keywords: Anti-Oxidants, Diabetes, Oxidative Stress, Chronic Metabolic Disorder, Insulin, Vitamin E, Vitamin C, Coenzyme Q10, Alpha Lipoic Acid, L-Carnitine, Reactive Oxygen Species, Antioxidants in the Treatment of Diabetes, Antioxidants
Abstract: Diabetes is a chronic metabolic disorder that continues to present as a major health problem worldwide. It is characterized by absolute or relative deficiencies in insulin secretion and/or insulin action and is associated with chronic hyperglycemia and disturbances of carbohydrate, lipid, and protein metabolism. Many studies suggest a central role for oxidative stress in the pathogenesis of this multi-faceted metabolic disorder. This has prompted investigations in the use of antioxidants as a complementary therapeutic approach. In this review we briefly summarize oxidative mechanisms implicated in diabetic complications and then focus on the findings resulting from human clinical trials where antioxidants were studied as an adjuvant to standard diabetes treatment during the last ten years. A literature search using PubMed (last ten years) was performed using the following terms: vitamin E, vitamin C, coenzyme Q10, alpha lipoic acid, L-carnitine, ruboxistaurin or LY 333531 and diabetes. This search was limited to human clinical trials. We conclude there is not any established benefit for antioxidant use in the management of diabetic complications. Therefore, routine vitamin or mineral supplementation is not generally recommended in human diabetes.
Export Options
About this article
Cite this article as:
Golbidi Saeid, Alireza Ebadi S. and Laher Ismail, Antioxidants in the Treatment of Diabetes, Current Diabetes Reviews 2011; 7 (2) . https://dx.doi.org/10.2174/157339911794940729
DOI https://dx.doi.org/10.2174/157339911794940729 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Identification of Molecular Targets Associated with Ethanol Toxicity and Implications in Drug Development
Current Pharmaceutical Design Stem Cells: A Golden Therapy for Diabetic Wounds
Current Diabetes Reviews Dietary Compounds, Epigenetic Modifications and Metabolic Diseases
Current Chemical Biology The beneficial effect of Cape gooseberry juice on carbon tetrachloride-induced neuronal damage
CNS & Neurological Disorders - Drug Targets Enhanced Tolerance against Early and Late Apoptotic Oxidative Stress in Mammalian Neurons through Nicotinamidase and Sirtuin Mediated Pathways
Current Neurovascular Research Targeting Mitochondria in Fighting Cancer
Current Pharmaceutical Design Withanolides: Biologically Active Constituents in the Treatment of Alzheimer’s Disease
Medicinal Chemistry Large-Conductance Ca2+-Activated K+ Channels:Physiological Role and Pharmacology
Current Medicinal Chemistry Role of Kynurenines in the Central and Peripherial Nervous Systems
Current Neurovascular Research The Role of Plant-Derived Compounds in Managing Diabetes Mellitus: A Review of Literature from 2014 To 2019
Current Medicinal Chemistry Improving Antihypertensive Agent Selection to Promote Nephroprotection
Current Hypertension Reviews Are Gap Junction Channels a Therapeutic Target and if so What Properties are Best Exploited?
Current Drug Targets A Direct Interaction Between Mitochondrial Proteins and Amyloid-β Peptide and its Significance for the Progression and Treatment of Alzheimer’s Disease
Current Medicinal Chemistry Evaluation of Venom as a Promising Tool for Drug Discovery: Focusing on Neurological Disorders
Venoms and Toxins Deacetylase Inhibitors Modulate the Myostatin/Follistatin Axis without Improving Cachexia in Tumor-Bearing Mice
Current Cancer Drug Targets The AMP-Activated Protein Kinase: Role in Regulation of Skeletal Muscle Metabolism and Insulin Sensitivity
Mini-Reviews in Medicinal Chemistry A Therapeutic Target for Microvascular Complications in Diabetes: Endothelium- Derived Hyperpolarizing Factor
Current Cardiology Reviews Protein Misfolding in Disease and Small Molecule Therapies
Current Topics in Medicinal Chemistry Pharmacodynamics of Memantine: An Update
Current Neuropharmacology Regression of Oxidative Stress by Targeting eNOS and Nrf2/ARE Signaling: A Guided Drug Target for Cardiovascular Diseases
Current Topics in Medicinal Chemistry