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Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Genetic Association Analysis of NOS3 and Methamphetamine-Induced Psychosis Among Japanese

Author(s): Y. Fukuo, N. Iwata, H. Ujike, N. Ozaki, I. Sora, M. Iyo, N. Uchimura, M. Yamada, T. Inada, T. Okochi, T. Tsunoka, T. Okumura, K. Kawashima, Y. Kinoshita, T. Kitajima, M. Ikeda and T. Kishi

Volume 9, Issue 1, 2011

Page: [151 - 154] Pages: 4

DOI: 10.2174/157015911795017119

Price: $65

Abstract

Endothelial nitric oxide synthase (NOS3) is one of the enzymes influencing nitric oxide (NO) function in the human brain. NO is a gaseous neurotransmitter that is involved in a variety of mechanisms in the central nervous system, such as N-methyl-D-aspartate receptor activation and oxidative stress. The evidence from animal pharmacological studies and postmortem studies supports an association between NO and psychotic disorders. Methamphetamine (METH) use disorder is a known psychotic disorder, and we therefore conducted a gene-based case-control study between tagging single nucleotide polymorphisms (SNPs) (rs2070744, rs1799983) in NOS3 and METH-induced psychosis in Japanese subjects (183 with METH-induced psychosis and 267 controls). Written informed consent was obtained from each subject. No significant association was found between any tagging SNP in NOS3 and METH-induced psychosis in the allele/genotype-wise or haplotype-wise analyses. In conclusion, we suggest that NOS3 might not contribute to the risk of METH-induced psychosis in the Japanese population.

Keywords: Methamphetamine-induced psychosis, endothelial nitric oxide synthase (NOS3), gene-based case-control association study, endothelial nitric oxide synthase, (NOS3), gene-based case-control association Study, psychiatric disorder, dopaminergic neurotoxicity, schizophrenia, neuronal dysfunction, behavioral abnormality


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