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Current Bioactive Compounds


ISSN (Print): 1573-4072
ISSN (Online): 1875-6646

Chemistry and Biological Activities of Buxus Alkaloids

Author(s): Yu-Xin Yan, Yun Sun, Zhong-Rong Li, Lin Zhou and Ming-Hua Qiu

Volume 7, Issue 1, 2011

Page: [47 - 64] Pages: 18

DOI: 10.2174/157340711795163811

Price: $65


Triterpenoid alkaloids are one of the most important classes that have been studied. Buxus alkaloids are such a type of triterpenoid alkaloids of cycloartenol skeleton with a degraded C-20 side chain, and with the nitrogen containing substituents at C-3 and/or C-20. 219 Buxus alkaloids have been reported so far. This review article focuses on the structural characters, plant sources and biological activities of Buxus alkaloids. This review includes anti-myocardial ischemia, inhibition of acetyl- and butyryl-cholinesterases, cytotoxicity and antibacterial activities. The biological activities, mechanisms and structure modifications of cyclovirobuxine D (CVB-D) are also described.

Keywords: Buxaceae, Buxus alkaloid, cyclovirobuxine D, structure modification, biological activity, triterpenoid alkaloids, plant sources, antibacterial, herbal medicine, anti-myocardial ischemia

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