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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Rho-Kinase as a Drug Target for the Treatment of Airway Hyperresponsiveness in Asthma

Author(s): Reinoud Gosens, Dedmer Schaafsma, S. A. Nelemans and Andrew J. Halayko

Volume 6, Issue 3, 2006

Page: [339 - 348] Pages: 10

DOI: 10.2174/138955706776073402

Price: $65


In asthma, inflammatory and structural cells contribute to increased bronchoconstriction acutely and more chronically to airway remodelling. Current asthma therapy doesnt inhibit these features satisfactorily. This review discusses Rho-kinase as a potential drug target, since increasing evidence suggests a central role for this pathway in acute and chronic airway hyperresponsiveness.

Keywords: Airway remodelling, airway smooth muscle, airway inflammation, Y-27632, fasudil

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