Abstract
Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β-unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well as recent synthetic antitumor agents. We observed that in spite of their rich medicinal tradition, cinnamic acid derivatives and their anticancer potentials remained underutilized for several decades since the first published clinical use in 1905. In last two decades, there has been huge attention towards various cinnamoyl derivatives and their antitumor efficacy. This review provides a comprehensive and unprecedented literature compilation concerning the synthesis and biological evaluation of various cinnamoyl acids, esters, amides, hydrazides and related derivatives in anticancer research. We envisage that our effort in this review contributes a much needed and timely addition to the literature of medicinal research.
Keywords: Anticancer agents, caffeic acid, cinnamic acid, cinnamide, cinnamoyl ester, cinnamic hydrazide
Current Medicinal Chemistry
Title: Cinnamic Acid Derivatives as Anticancer Agents-A Review
Volume: 18 Issue: 11
Author(s): P. De, M. Baltas and F. Bedos-Belval
Affiliation:
Keywords: Anticancer agents, caffeic acid, cinnamic acid, cinnamide, cinnamoyl ester, cinnamic hydrazide
Abstract: Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β-unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical aspects cinnamic acid derivatives received much attention in medicinal research as traditional as well as recent synthetic antitumor agents. We observed that in spite of their rich medicinal tradition, cinnamic acid derivatives and their anticancer potentials remained underutilized for several decades since the first published clinical use in 1905. In last two decades, there has been huge attention towards various cinnamoyl derivatives and their antitumor efficacy. This review provides a comprehensive and unprecedented literature compilation concerning the synthesis and biological evaluation of various cinnamoyl acids, esters, amides, hydrazides and related derivatives in anticancer research. We envisage that our effort in this review contributes a much needed and timely addition to the literature of medicinal research.
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Cite this article as:
De P., Baltas M. and Bedos-Belval F., Cinnamic Acid Derivatives as Anticancer Agents-A Review, Current Medicinal Chemistry 2011; 18 (11) . https://dx.doi.org/10.2174/092986711795471347
DOI https://dx.doi.org/10.2174/092986711795471347 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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