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Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Structural Chromosome Abnormalities Associated with Obesity: Report of Four New Subjects and Review of Literature

Author(s): Majed J. Dasouki, Erin L. Youngs and Karine Hovanes

Volume 12, Issue 3, 2011

Page: [190 - 203] Pages: 14

DOI: 10.2174/138920211795677930

Price: $65


Obesity in humans is a complex polygenic trait with high inter-individual heritability estimated at 40 – 70%. Candidate gene, DNA linkage and genome-wide association studies (GWAS) have allowed for the identification of a large set of genes and genomic regions associated with obesity. Structural chromosome abnormalities usually result in congenital anomalies, growth retardation and developmental delay. Occasionally, they are associated with hyperphagia and obesity rather than growth delay. We report four new individuals with structural chromosome abnormalities involving 10q22.3-23.2, 16p11.2 and Xq27.1-q28 chromosomal regions with early childhood obesity and developmental delay. We also searched and summarized the literature for structural chromosome abnormalities reported in association with childhood obesity

Keywords: Obesity, aCGH, chromosome, deletion, duplication, translocation, fluorescent in situ hybridization, CNV, congenital anomalies, growth retardation

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