Abstract
Infection with Neisseria meningitidis remains one of the most devastating illnesses in pediatrics. Affected patients can progress from a mild viral-like illness to death within a matter of hours. Additionally, the definitive clinical diagnosis cannot be reached until the characteristic petechial rash appears, making differentiating meningococcal infection from a benign viral illness impossible. This review will discuss the epidemiology, bacteriology, pathophysiology, treatment, and potential new therapies for severe meningococcal infections in children and adolescents.
Keywords: N. meningitidis, lipopolysaccharide (LPS)-binding receptors, Polysaccharide vaccines, Anti-Sepsis Drugs, rBPI21
Current Pediatric Reviews
Title: Severe Meningococcal Infections in Children and Adolescents
Volume: 2 Issue: 2
Author(s): Alan Graham and Brahm Goldstein
Affiliation:
Keywords: N. meningitidis, lipopolysaccharide (LPS)-binding receptors, Polysaccharide vaccines, Anti-Sepsis Drugs, rBPI21
Abstract: Infection with Neisseria meningitidis remains one of the most devastating illnesses in pediatrics. Affected patients can progress from a mild viral-like illness to death within a matter of hours. Additionally, the definitive clinical diagnosis cannot be reached until the characteristic petechial rash appears, making differentiating meningococcal infection from a benign viral illness impossible. This review will discuss the epidemiology, bacteriology, pathophysiology, treatment, and potential new therapies for severe meningococcal infections in children and adolescents.
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Cite this article as:
Graham Alan and Goldstein Brahm, Severe Meningococcal Infections in Children and Adolescents, Current Pediatric Reviews 2006; 2 (2) . https://dx.doi.org/10.2174/157339606776894595
DOI https://dx.doi.org/10.2174/157339606776894595 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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