Cell Penetrating Peptides for Tumor Targeting

Title: Cell Penetrating Peptides for Tumor Targeting

Volume: 12 Issue: 8

Author(s): Young Suk Choi, Jue Yeon Lee, Jin Sook Suh, Seung Jin Lee, Victor C. Yang, Chong Pyoung Chung and Yoon Jeong Park

Affiliation:

Keywords: Antitumor drug delivery, cell penetrating peptides (cpp), molecular cargo, intracellular drug delivery, bioavailability of drugs, therapeutic efficacy, cell penetrating peptides (CPPs), solid nanoparticles, cargo translocation, cell-penetrating peptides

Abstract: Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy. While different types of transporters currently exist, cell penetrating peptides (CPPs) have become one of the most popular and effective tools for intracellular drug delivery. Most of the original CPPs are short peptides with basic residues. The mechanism of CPP cell entry remains to be established; however, the CPPs can deliver any type of molecular cargo including solid nanoparticles. Herein, this paper will discuss the classification of CPPs, the mechanism of cell entry, the application of CPPs in tumor therapy, and recent advances in targeted cell penetration that involve CPPs.

Cite this article as:

Suk Choi Young, Yeon Lee Jue, Sook Suh Jin, Jin Lee Seung, C. Yang Victor, Pyoung Chung Chong and Jeong Park Yoon, Cell Penetrating Peptides for Tumor Targeting, Current Pharmaceutical Biotechnology 2011; 12 (8) . https://dx.doi.org/10.2174/138920111796117391