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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Role of the Non-Receptor Tyrosine Kinase Fes in Cancer

Author(s): F. Condorelli, E. Stec-Martyna, J. Zaborowska, L. Felli, I. Gnemmi, M. Ponassi and C. Rosano

Volume 18, Issue 19, 2011

Page: [2913 - 2920] Pages: 8

DOI: 10.2174/092986711796150522

Price: $65


Non receptor protein tyrosine kinases are targets in the treatment of a number of diseases. This review focuses on the role of Fes tyrosine kinase and on the design of inhibitors of this protein. Fes and its homologously related protein Fer are the only two members of a distinct class of non receptor tyrosine kinases and they seem to play a role in cytoskeletal rearrangements and inside-out signalling associated with receptor-ligand, cell-matrix and cell-cell interactions. The knowledge of the three dimensional structure of this protein, in fact, has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions.

Keywords: Fes kinase, non receptor tyrosine kinase, structure based drug design, protein structure, protein crystallography

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