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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development

Author(s): A.Y. Kots, K. Bian and F. Murad

Volume 18, Issue 22, 2011

Page: [3299 - 3305] Pages: 7

DOI: 10.2174/092986711796504646

Price: $65


Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.

Keywords: Nitric oxide, cGMP, nitric oxide synthase, guanylyl cyclase, phosphodiesterase, traditional Chinese medicine, drug development, numerous efforts, drug and formulation discovery, promising approaches

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