Abstract
Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
Keywords: Biomarker, colorectal carcinogenesis, DNA repair, gene polymorphism, genetic instability, genetic predisposition, mutations, familial adenomatous polyposis (FAP) syndrome, microsatellite instability, replication, DNA double helix, chromatid, DNA polymerase, pyrimidine dimers, photolyase
Current Molecular Medicine
Title: DNA Repair Mechanisms in Colorectal Carcinogenesis
Volume: 12 Issue: 3
Author(s): C. Michailidi, A. G. Papavassiliou and C. Troungos
Affiliation:
Keywords: Biomarker, colorectal carcinogenesis, DNA repair, gene polymorphism, genetic instability, genetic predisposition, mutations, familial adenomatous polyposis (FAP) syndrome, microsatellite instability, replication, DNA double helix, chromatid, DNA polymerase, pyrimidine dimers, photolyase
Abstract: Colon cancer is among the most common cancers and the third cause of cancer deaths worldwide. If detected at an early stage, treatment might often lead to cure. The present review adduces the so far studied alterations in the expression of genes, as well as polymorphisms of genes engaged in DNA repair systems, with particular emphasis on indirect ones that are correlated with colorectal cancer. Such aberrations could be linked to an increased risk for the development of colorectal cancer and might serve as potential targets in the areas of prevention and therapy.
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Cite this article as:
Michailidi C., G. Papavassiliou A. and Troungos C., DNA Repair Mechanisms in Colorectal Carcinogenesis, Current Molecular Medicine 2012; 12 (3) . https://dx.doi.org/10.2174/156652412799218859
DOI https://dx.doi.org/10.2174/156652412799218859 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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