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Current Drug Targets


ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Screening Strategies to Identify New Antibiotics

Author(s): Mark S. Butler and Matthew A. Cooper

Volume 13, Issue 3, 2012

Page: [373 - 387] Pages: 15

DOI: 10.2174/138945012799424624

Price: $65


The emergence of multi-drug resistant bacteria is one of the most critical medical problems currently facing humankind, which will only get worse if no new antibacterial drugs are launched. This article will first review commonly used screening strategies used to identify potential new antibiotics and then discuss novel screening methods. In addition, new assays, methods, biological targets and compounds with novel modes of action undergoing pre-clinical or clinical development are briefly discussed.

Keywords: Antibiotics, drug resistance, biofilm, virulence, efflux, synergy, antisense, fragment based drug design, screening, mutants

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