Abstract
Carotenoid bioactivity, namely the quenching of reactive oxygen species (ROS) and other excited-state oxidants, suggests significant clinical potential for these natural products. However, a thorough therapeutic evaluation of the carotenoids has been hampered by limited water-solubility and/or water-dispersibility (“hydrophilicity”) as well as poor bioavailability. Hydrophilic carotenoid derivatives have been designed and prepared for parenteral administration. Synthetic methods, selected physical characteristics, and potential biological applications of these novel therapeutics will be discussed.
Keywords: Aggregation, antioxidants, carotenoids, hydrophilic carotenoids, reactive oxygen species (ROS), retrometabolic drug design, soft drugs, tissue tropism
Mini-Reviews in Medicinal Chemistry
Title: Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications
Volume: 6 Issue: 9
Author(s): Bente Jeanette Foss, Geoff Nadolski and Samuel F. Lockwood
Affiliation:
Keywords: Aggregation, antioxidants, carotenoids, hydrophilic carotenoids, reactive oxygen species (ROS), retrometabolic drug design, soft drugs, tissue tropism
Abstract: Carotenoid bioactivity, namely the quenching of reactive oxygen species (ROS) and other excited-state oxidants, suggests significant clinical potential for these natural products. However, a thorough therapeutic evaluation of the carotenoids has been hampered by limited water-solubility and/or water-dispersibility (“hydrophilicity”) as well as poor bioavailability. Hydrophilic carotenoid derivatives have been designed and prepared for parenteral administration. Synthetic methods, selected physical characteristics, and potential biological applications of these novel therapeutics will be discussed.
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Cite this article as:
Jeanette Foss Bente, Nadolski Geoff and Lockwood F. Samuel, Hydrophilic Carotenoid Amphiphiles: Methods of Synthesis and Biological Applications, Mini-Reviews in Medicinal Chemistry 2006; 6 (9) . https://dx.doi.org/10.2174/138955706778195225
DOI https://dx.doi.org/10.2174/138955706778195225 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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