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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery

Author(s): Iva Ivanovska, Clare N. Muhoro and Pablo M. Irusta

Volume 6, Issue 9, 2006

Page: [1033 - 1042] Pages: 10

DOI: 10.2174/138955706778195216

Price: $65


Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.

Keywords: Cancer, apoptosis, IAP, Caspases, Bcl-2

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