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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

ABC Transporters and Isothiocyanates

Author(s): Ian Derek Kerr and Nigel Simon Simpkins

Volume 3, Issue 9, 2006

Page: [607 - 621] Pages: 15

DOI: 10.2174/157018006778341147

Price: $65

Abstract

Identification of naturally occurring compounds as potential anti-cancer chemotherapy drugs is a prominent research area. Simple dietary isothiocyanates have a spectrum of cellular targets including effects on ATP binding cassette (ABC) transporters, which mediate resistance to chemotherapy. Recent investigations have identified complex compounds, containing an isothiocyanate, which may be more specific inhibitors of ABC transporters.

Keywords: Isothiocyanate, ABC Transporter, Chemoprevention, Multidrug Resistance, Welwistatin


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