Abstract
The pathogenesis of obesity, insulin resistance and hypertension begins with an interaction between genetic factors and environmental factors. The search for the underlying genetic basis of these conditions has yielded disappointing results. It is possible that the importance of environmental influences has been underestimated. In Part Two of our series of reviews, we discuss the key genetic, environmental and evolutionary influences which lead to the development of these conditions, and provide a detailed account of the mechanisms by which these influences produce their effects.
Keywords: Metabolic syndrome, hypertension, obesity, insulin resistance, epidemiology, gene-environment interaction, reninangiotensin system, candidate gene approach, genome wide scanning, intermediate phenotype
Current Vascular Pharmacology
Title: The Etiology of Hypertension in the Metabolic Syndrome Part Two: The Gene-Environment Interaction
Volume: 4 Issue: 4
Keywords: Metabolic syndrome, hypertension, obesity, insulin resistance, epidemiology, gene-environment interaction, reninangiotensin system, candidate gene approach, genome wide scanning, intermediate phenotype
Abstract: The pathogenesis of obesity, insulin resistance and hypertension begins with an interaction between genetic factors and environmental factors. The search for the underlying genetic basis of these conditions has yielded disappointing results. It is possible that the importance of environmental influences has been underestimated. In Part Two of our series of reviews, we discuss the key genetic, environmental and evolutionary influences which lead to the development of these conditions, and provide a detailed account of the mechanisms by which these influences produce their effects.
Export Options
About this article
Cite this article as:
The Etiology of Hypertension in the Metabolic Syndrome Part Two: The Gene-Environment Interaction, Current Vascular Pharmacology 2006; 4 (4) . https://dx.doi.org/10.2174/157016106778521661
DOI https://dx.doi.org/10.2174/157016106778521661 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Patients with Rheumatic Diseases Overlooked during COVID-19 Pandemic: How are They Doing and Behaving?
Current Rheumatology Reviews A Perspective on the Current Strategies for the Treatment of Obesity
Current Drug Targets - CNS & Neurological Disorders Modelling the Neurovascular Unit and the Blood-Brain Barrier with the Unique Function of Pericytes
Current Neurovascular Research Patent Selections:
Recent Patents on Inflammation & Allergy Drug Discovery Dissecting abdominal aortic aneurysm in Angiotensin II-infused mice: the importance of imaging
Current Pharmaceutical Design Endocrine Therapies and QTc Prolongation
Current Drug Safety Modern Computational Strategies for Designing Drugs to Curb Human Diseases: A Prospect
Current Topics in Medicinal Chemistry Lower Frequency of co-Morbid Medical Disorders Related to Poor Impulse Control in Parkinson’s than Alzheimer’s Disease
Current Aging Science DL-3-n-Butylphthalide, an Anti-Oxidant Agent, Prevents Neurological Deficits and Cerebral Injury Following Stroke per Functional Analysis, Magnetic Resonance Imaging and Histological Assessment
Current Neurovascular Research Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia
Current Alzheimer Research Hypertension and Aortic Stenosis: A Review
Current Hypertension Reviews Oxidative Stress and Transforming Growth Factor-β<sub>1</sub>-induced Cardiac Fibrosis
Cardiovascular & Hematological Disorders-Drug Targets Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents
Current Topics in Medicinal Chemistry Current Options for the Pharmacotherapy of Obesity
Current Pharmaceutical Design Quick-Release Bromocriptine for Treatment of Type 2 Diabetes
Current Drug Delivery Sunitinib in the Treatment of Thyroid Cancer
Current Medicinal Chemistry Chronic Stress and Alzheimers Disease-Like Pathogenesis in a Rat Model: Prevention by Nicotine
Current Neuropharmacology Sodium Ion Transporters as New Therapeutic Targets in Heart Failure
Cardiovascular & Hematological Agents in Medicinal Chemistry Meet the Editorial Board
Current Vascular Pharmacology Thyrotoxic Periodic Paralysis: A Concise Review of the Literature
Current Rheumatology Reviews