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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Adenosine-to-Inosine RNA Editing: Perspectives and Predictions

Author(s): Barry Hoopengardner

Volume 6, Issue 11, 2006

Page: [1213 - 1216] Pages: 4

DOI: 10.2174/138955706778742812

Price: $65


Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.

Keywords: Adenosine, inosine, RNA, editing, drosophila, ion channel, convergence

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