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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Lamotrigine Pharmacokinetics During Anticonception and Pregnancy

Author(s): A. Sabers

Volume 3, Issue 5, 2006

Page: [321 - 322] Pages: 2

DOI: 10.2174/157018006777574267

Price: $65


Lamotrigine (LTG) is a modern, effective and well-tolerated antiepileptic drug (AED) with an expected low teratogenic potential and therefore regarded as a relative safe drug for women of reproductive age. Recent studies, however, have demonstrated that co-administration of LTG and combined oral contraceptives (OCs) and pregnancy interfere with the metabolism of LTG with the risk of therapeutic failure. It is therefore recommended that plasma level of LTG should be closely monitored before and after introduction or discontinuation of OCs and monthly during pregnancy.

Keywords: Lamotrigine, pharmacokinetics, anticonception, pregnancy, interaction

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