Abstract
Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Mini-Reviews in Medicinal Chemistry
Title: New Insights into the Regulation of Liver Inflammation and Oxidative Stress
Volume: 6 Issue: 12
Author(s): Natalia Ferre and Joan Claria
Affiliation:
Keywords: Cyclooxygenase, 5-lipoxygenase, TNF-α, TGF-β, reactive oxygen species
Abstract: Pro-inflammatory lipid mediators (i.e. eicosanoids), cytokines (i.e. TNF-α) and reactive oxygen species are targets of interest in the regulation of liver inflammation and oxidative stress. In the current review, we summarize recent advances in the pharmacological modulation of these pathways with especial emphasis on the participation of Kupffer cells, the liver resident macrophages and the cell type most directly related to the production of inflammatory mediators in this organ.
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Cite this article as:
Ferre Natalia and Claria Joan, New Insights into the Regulation of Liver Inflammation and Oxidative Stress, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778993049
DOI https://dx.doi.org/10.2174/138955706778993049 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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