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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs

Author(s): D. J. Miller and R. K. Allemann

Volume 7, Issue 2, 2007

Page: [107 - 113] Pages: 7

DOI: 10.2174/138955707779802624

Price: $65

Abstract

myo-Inositol monophosphatase has long been a target for drug discovery. Recent work has given detailed insight into its mechanism and dynamics plus new activities and some novel series of inhibitors. The goal of a bio-available inhibitor for this enzyme, however, remains a major challenge for medicinal chemistry.

Keywords: diacylglycerol, G-protein coupled receptor, Lithitum, myo-Inositol 1-phosphate, Circular dichroism, Zinc ion

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