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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Co-Existence of GABA and Glu in the Hippocampal Granule Cells: Implications for Epilepsy

Author(s): Rafael Gutierrez and Uwe Heinemann

Volume 6, Issue 10, 2006

Page: [975 - 978] Pages: 4

DOI: 10.2174/156802606777323692

Price: $65


The granule cells of the Dentate Gyrus are one of the most exciting and intriguing cells in the central nervous system. Besides containing and releasing Glu, they have been shown to contain and release peptides (somatostatin, neuropeptide Y, neurokinin B, cholecystokinin, dynorphin, enkephalin), Zn++ ion, and brain-derived neurotrophic factor (BDNF). The recent addition of GABA to this list suggests that these cells can also function as inhibitory cells. Indeed, evidence has been presented of co-localization of all markers of the GABAergic phenotype in granule cells: GABA, the enzyme for its synthesis (Glu decarboxylase) and the membrane and vesicular transporters of GABA. These markers of the GABAergic phenotype are up-regulated after epileptic seizures. When this occurs, monosynaptic GABA receptormediated transmission emerges in the mossy fiber synapse thus restraining excitation and mediating antiepileptic and neuroprotective actions.

Keywords: Inducible GABAergic phenotype, Dentate Gyrus, mossy fiber stimulation, nonsynaptic IPSPs, GABAA-mediated field potential, CA3, collated inhibition

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