Abstract
Brain imaging has played a major role in exploring abnormalities of brain structure and function in aging and dementia. Recently, with reports linking obesity to cognitive decline and dementia, magnetic resonance imaging has been used to investigate how brain structure may be altered with obesity. These studies have convincingly demonstrated both generalized and regional brain atrophy and changes in white matter in association with obesity. These results do not appear to be simply explained by links to cardiovascular disease. However, the mechanisms underlying these alterations are unclear and could be accounted for by a number of different processes that are known to alter brain structure and which could also be related to obesity. Application of additional imaging methods could help to establish the pathway through which obesity produces cognitive decline and dementia.
Keywords: Imaging, MRI, PET, obesity, dementia, Alzheimer's disease
Current Alzheimer Research
Title: What Can Imaging Reveal about Obesity and the Brain?
Volume: 4 Issue: 2
Author(s): William Jagust
Affiliation:
Keywords: Imaging, MRI, PET, obesity, dementia, Alzheimer's disease
Abstract: Brain imaging has played a major role in exploring abnormalities of brain structure and function in aging and dementia. Recently, with reports linking obesity to cognitive decline and dementia, magnetic resonance imaging has been used to investigate how brain structure may be altered with obesity. These studies have convincingly demonstrated both generalized and regional brain atrophy and changes in white matter in association with obesity. These results do not appear to be simply explained by links to cardiovascular disease. However, the mechanisms underlying these alterations are unclear and could be accounted for by a number of different processes that are known to alter brain structure and which could also be related to obesity. Application of additional imaging methods could help to establish the pathway through which obesity produces cognitive decline and dementia.
Export Options
About this article
Cite this article as:
Jagust William, What Can Imaging Reveal about Obesity and the Brain?, Current Alzheimer Research 2007; 4 (2) . https://dx.doi.org/10.2174/156720507780362146
DOI https://dx.doi.org/10.2174/156720507780362146 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Allosteric Modulation of Muscarinic Acetylcholine Receptors
Current Neuropharmacology A Prospective Study for Introducing Insulin Pens and Safety Needles in a Hospital Setting. The SANITHY Study
Current Diabetes Reviews miRNAs: New Biomarkers and Therapeutic Targets in Dementia
Current Pharmaceutical Design A Review of Selected Adult Congenital Heart Diseases Encountered in Daily Practice
Current Cardiology Reviews Transgenic C. elegans as a Model in Alzheimers Research
Current Alzheimer Research Association of Red Blood Cell Indices with Mild Cognitive Impairment in Chinese Elderly Individuals: A Matched Case-control Study
Current Alzheimer Research Human Endotoxemia as a Model of Systemic Inflammation
Current Medicinal Chemistry Clinical Significance of the Cardio-Ankle Vascular Index (CAVI) in Hypertension
Current Hypertension Reviews The Impact of Docosahexaenoic Acid on Alzheimer’s Disease: Is There a Role of the Blood-Brain Barrier?
Current Clinical Pharmacology Tyrosine Kinase Inhibitor as a new Therapy for Ischemic Stroke and other Neurologic Diseases: is there any Hope for a Better Outcome?
Current Neuropharmacology The Forgotten Cells: Role of Astrocytes in Mood Disorders During the Aging
Current Neuropharmacology Editorial (Hot Topic : Computational Prediction of Drug-Target Interactions in Medicinal Chemistry)
Current Topics in Medicinal Chemistry The Therapeutic Potential of Neuro-EPO Administered Nasally on Acute Cerebrovascular Disease
Current Psychopharmacology Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease
Current Alzheimer Research Neuropsychiatric and Cognitive Symptoms in Spinocerebellar Ataxia: Relationship to Neuropathological Differences
Current Psychiatry Reviews subject Index To Volume 1
Current Drug Targets - Inflammation & Allergy β-amyloid and Oxidative Stress: Perspectives in Drug Development
Current Pharmaceutical Design Therapeutic Approaches to Alzheimer’s Type of Dementia: A Focus on FGF21 Mediated Neuroprotection
Current Pharmaceutical Design Alzheimer Biomarkers and Clinical Alzheimer Disease were Not Associated with Increased Cerebrovascular Disease in a Memory Clinic Population
Current Alzheimer Research Neuropsychiatric Symptoms in Amnestic Mild Cognitive Impairment: Increased Risk and Faster Progression to Dementia
Current Alzheimer Research