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Current Signal Transduction Therapy


ISSN (Print): 1574-3624
ISSN (Online): 2212-389X

Smad-Signaling in Mammary Gland Development and Tumorigenesis

Author(s): Vandana Gupta, Arunthathi Thiagalingam and Shyamala Maheswaran

Volume 2, Issue 2, 2007

Page: [111 - 120] Pages: 10

DOI: 10.2174/157436207780619482

Price: $65


The Transforming Growth Factor-β (TGFβ) superfamily of cytokines regulates a myriad of cellular processes including proliferation, differentiation and tumorigenesis. Signaling by these growth regulatory molecules is propagated by ligand-induced heterooligomerization of distinct type II and type I serine/threonine kinase receptors, which result in activation of receptor-activated Smad proteins as well as Smad-independent pathways. Disruption of TGFβ induced signaling can contribute to development and progression of human breast cancer. The role of Smad-signaling in mammary gland development and tumorigenesis will be the focus of this review.

Keywords: TGFβ, activin, inhibin, BMP, MIS, nodal, cripto-1, smads, breast cancer

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