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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug

Author(s): Rudolf Lucas, Harald Hundsberger, Maren Pfluger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schutt, Christoph Wiesner and Jurg Hamacher

Volume 4, Issue 5, 2007

Page: [336 - 340] Pages: 5

DOI: 10.2174/157018007780867816

Price: $65


In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.

Keywords: TNF, Pulmonary edema, Sodium channels, Lectin, Peptide

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